| Sangre de Cristo Creek | |
| Source1 Location: | La Veta Pass |
| Source1 Coordinates: | 37.6156°N -105.1931°W |
| Source1 Coord Ref: | [1] |
| Mouth Location: | Smith Reservoir |
| Mouth Coordinates: | 37.3983°N -105.5236°W |
| Progression: | Trinchera Creek — Rio Grande |
| Mouth Elevation: | 7730abbr=offNaNabbr=off |
Sangre de Cristo Creek is a stream in Costilla County, Colorado. It starts atop La Veta Pass in the Sangre de Cristo Mountains. The creek flows alongside Highway 160 as it descends from the top of the pass into the San Luis Valley.
The creek's mouth is at Smith Reservoir, south of Blanca. Before the reservoir was built, the creek had a confluence here with Trinchera Creek, of which it is a tributary.
In 1879 there was a railroad accident on a grade above the creek, killing one person.[2]