| Sandra Sepúlveda | |
| Fullname: | Sandra Milena Sepúlveda Lopera |
| Birth Date: | 3 March 1988 |
| Birth Place: | Bello, Antioquia, Colombia |
| Currentclub: | Independiente Medellín |
| Position: | Goalkeeper |
| Years1: | 2009–2014 |
| Clubs1: | Formas Íntimas |
| Years2: | 2015–2017 |
| Clubs2: | Kiryat Gat |
| Years3: | 2018 |
| Clubs3: | Junior |
| Years4: | 2019–2020 |
| Clubs4: | Independiente Medellín |
| Years5: | 2021 |
| Clubs5: | Deportivo Cali |
| Caps5: | 13 |
| Goals5: | 0 |
| Years6: | 2023– |
| Clubs6: | Independiente Medellín |
| Caps6: | 14 |
| Goals6: | 0 |
| Nationalyears1: | 2009– |
| Nationalteam1: | Colombia |
| Nationalcaps1: | 49[1] |
| Nationalgoals1: | 0 |
| Ntupdate: | 18 July 2023 |
Sandra Milena Sepúlveda Lopera (born 3 March 1988) is a Colombian footballer who plays as a goalkeeper for Liga Profesional Femenina club Independiente Medellín and the Colombia women's national team.
Sepúlveda joined her first club, Formas Íntimas, as a 10-year-old. She rose to club captain and played in the Copa Libertadores Femenina.[2] She accepted a contract offer from the Israeli club Kiryat Gat in November 2015.[3] In January 2018 she agreed to sign for Atlético Junior's newly formed women's team, who were entering the Colombian Women's Football League.[4]
Sepúlveda played for Colombia at the 2012 and 2016 Olympics.[5] She was voted best goalkeeper at the 2014 Women's Copa America.[6] She was part of Colombia's team at the 2015 World Cup.