Sandip Basu Explained

Sandip Basu
Nationality:	Indian
Known For:	Studies on Positron emission tomography Diagnostics and Radionuclide Therapy

Sandip Basu is an Indian physician of Nuclear Medicine and the Head, Nuclear Medicine Academic Program at the Radiation Medicine Centre (Bhabha Atomic Research Centre). He is also the Dean-Academic (Health-Sciences), BARC at Homi Bhabha National Institute and is known for his services and research in Nuclear Medicine, particularly on Positron emission tomography diagnostics and Targeted Radionuclide Therapy in Cancer. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Nuclear Medicine in 2012.^[1]

Biography

Sandip Basu, is a Professor of Nuclear Medicine at the Radiation Medicine Centre, and Head, Nuclear Medicine Academic Programme, affiliated to the Health Sciences, BARC.^[2] He also serves as the dean-academics (Health Sciences), BARC at Homi Bhabha National Institute of the Department of Atomic Energy.^[3] He pursues his clinical patient services, academics and research interests at the Radiation Medicine Centre Bhabha Atomic Research Centre housed at Tata Memorial Hospital Annexe Building at Parel, Mumbai.^[4] He is known for his clinical and applied research in the field of Nuclear Medicine, especially on positron emission tomography-based diagnostics and Targeted Radionuclide therapy.^{[5] [6]} One major area of his research interests and clinical work has been the integration of functional radionuclide imaging and targeted radionuclide treatment which assisted in developing personalized management model and providing individualized treatment to patients of cancer.^[7] His studies have been documented by way of a number of articles of which many have been listed by online article repositories such as Google Scholar^[8] and ResearchGate.^[9] Besides, he has guest-edited six books viz. Breast Cancer Imaging I: Number 3,^[10] Breast Cancer Imaging II: Pet Clinics,^[11] Radiation Therapy Planning with PET: Number 2,^[12] Modern Quantitative Techniques for PET,^[13] PET Imaging of Brain Tumors, An Issue of PET Clinics^[14] and PET-Based Molecular Imaging in Evolving Personalized Management Design, An Issue of PET Clinics^[15] and has contributed chapters to books published by others.^{[16] [17] [18]}

Basu served as the national project coordinator of the IAEA-Regional Co-operative Agreement project at Bhabha Atomic Energy Centre on Strengthening the Applications of Nuclear Medicine in the Management of Cardiovascular Diseases.^[19] He serves as a member of the editorial boards of a number of journals including European Journal of Nuclear Medicine and Molecular Imaging,^[20] Nuclear Medicine Communications^[21] and Hellenic journal of Nuclear Medicine.^[22] He is also a former editor of World Journal of Radiology. He has been an author of more than 400 peer-reviewed papers and delivered several invited speeches in national/international conferences and symposiums.

In his capacity as the Dean-Academics, Medical and Health Sciences, BARC, Dr Basu took pivotal role in initiating the M.D. (Nuclear Medicine) course for doctors and the M.Sc.(Nuclear Medicine and Molecular Imaging Technology) and M.Sc. (Hospital Radiopharmacy) courses for science graduates, at the Radiation Medicine Centre (BARC) under the aegis of HBNI University, aimed at developing trained manpower in the field of Nuclear Medicine. The M.Sc. (Hospital Radiopharmacy) course at the Centre was first of its kind in India, providing structured training in the subject.

Between 2010 and 2020, Dr. Basu was instrumental in developing a large-volume clinical PRRT service in the centre by the joint efforts of Radiation Medicine Centre (RMC), Bhabha Atomic Research Centre (BARC), and Tata Memorial Hospital (TMH) at the TMH-RMC premises, delivering over 4,000 [177Lu]Lu-DOTATATE therapies for patients with metastatic/advanced neuroendocrine neoplasms and related malignancies making this the largest PRRT set-up in the country, an exemplar of successful PRRT programme employing indigenous 177Lutetium production at BARC and resources. Since 2017, he steered the development of [68Ga]Ga-/[177Lu]Lu-PSMA-based theranostics and peptide receptor radioligand therapy (PRLT) in metastatic castration resistant prostate carcinoma (mCRPC) patients in the centre.

Awards and honors

The Society of Nuclear Medicine and Molecular Imaging selected him for the Alavi-Mandell Award in 2010.^[23] The Council of Scientific and Industrial Research awarded Basu the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards in 2012.^[24] Dr. Basu was recipient of the DAE Homi Bhabha Science and Technology Award 2017 and the Homi Bhabha Memorial Oration 2019 at the 51st Annual Meeting of the Society of Nuclear Medicine India.

Selected bibliography

Books

• Book: Sandip Basu. Abass Alavi. PET-Based Molecular Imaging in Evolving Personalized Management Design, An Issue of PET Clinics. 9 July 2016. Elsevier Health Sciences. 978-0-323-44871-0.
• Book: Sandip Basu. Rakesh Kumar. Abass Alavi. Breast Cancer Imaging I: Number 3. 1 December 2009. W.B. Saunders Company. 9781437709643.
• Book: Sandip Basu. Rakesh Kumar. Ayse Mavi, Abass Alavi. Breast Cancer Imaging II: Pet Clinics. 28 January 2010. Elsevier - Health Sciences Division. 978-1-4377-1402-9.
• Book: Roger M. Macklis. Sushil Beriwal. Sandip Basu. Radiation Therapy Planning with PET: Number 2. 13 June 2011. W.B. Saunders Company.
• Book: Babak Saboury. Abass Alavi. Mateen Moghbel, Sandip Basu. Modern Quantitative Techniques for PET. 2012. INTECH Open Access Publisher. 978-953-51-0359-2.
• Book: Sandip Basu. Wei Chen. PET Imaging of Brain Tumors, An Issue of PET Clinics. 22 April 2013. Elsevier Health Sciences. 978-1-4557-7221-6.
• Book: Thomas . Wagner . Basu . Sandip . PET/CT in Infection and Inflammation . 2018 . Springer International Publishing . 978-3-319-90412-2. en.

Articles

• Basu S . Nov 2010 . Personalized versus evidence-based medicine with PET-based imaging . Nature Reviews Clinical Oncology . 7 . 11. 665–8 . 10.1038/nrclinonc.2010.121 . 20700107 . 12124668 .
• Sandip Basu, Narendra Nair . Relapse of cervical cancer presenting as symptoms of Collet-Sicard syndrome with metastatic subcutaneous and adrenal deposits . The Lancet Oncology . 2006 . 7 . 7 . 610 . 10.1016/S1470-2045(06)70764-1. 16814215 .
• 18098228 . 10.1002/cncr.23226 . 112 . 5 . Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters: a potentially useful method for disease characterization . March 2008 . Cancer . 995–1000 . Basu S, Chen W, Tchou J . etal . free .
• 24863431 . 10.1007/s00259-014-2805-8 . 41 . 8 . Dual tracer imaging approach in assessing tumor biology and heterogeneity in neuroendocrine tumors: its correlation with tumor proliferation index and possible multifaceted implications for personalized clinical management decisions, with focus on PRRT . 2014 . Eur J Nucl Med Mol Imaging . 1492–6 . Basu S, Sirohi B, Shrikhande SV . free .
• Basu S, Houseni M, Bural G, Chamroonat W, Udupa J, Mishra S, Alavi A. "Magnetic resonance imaging based bone marrow segmentation for quantitative calculation of pure red marrow metabolism using 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography: a novel application with significant implications for combined structure-function approach. Mol Imaging Biol. 2007 Nov-Dec;9(6):361-5.
• Sandip Basu, Mitali Dandekar, Amit Joshi, Anil D’Cruz . Defining a rational step-care algorithm for managing thyroid carcinoma patients with elevated thyroglobulin and negative on radioiodine scintigraphy (TENIS): considerations and challenges towards developing an appropriate roadmap . European Journal of Nuclear Medicine and Molecular Imaging . 2015 . 42 . 8 . 1167–1171 . 10.1007/S00259-015-3058-X. 25989850 . free .
• 18832112 . 49 . 10 . Unparalleled contribution of 18F-FDG PET to medicine over 3 decades . 2008 . J Nucl Med . 17N-21N, 37N . Basu S, Alavi A .
• 15107330 . 10.1259/bjr/72600472 . 77 . 916 . 99Tc(m)(V)DMSA scintigraphy in skeletal metastases and superscans arising from various malignancies: diagnosis, treatment monitoring and therapeutic implications . 2004 . Br J Radiol . 347–61 . Basu S, Nair N, Awasare S, Tiwari BP, Asopa R, Nair C .
• Basu S, Zaidi H, Houseni M, Bural G, Udupa J, Acton P, Torigian DA, Alavi A.Novel quantitative techniques for assessing regional and global function and structure based on modern imaging modalities: implications for normal variation, aging and diseased states. Semin Nucl Med. 2007 May;37(3):223-39
• 25920048 . 10.1097/MNM.0000000000000321 . 36 . 8 . Correlation and discordance of tumour proliferation index and molecular imaging characteristics and their implications for treatment decisions and outcome pertaining to peptide receptor radionuclide therapy in patients with advanced neuroendocrine tumour: developing a personalized model . 2015 . Nucl Med Commun . 766–74 . Basu S, Ranade R, Thapa P . 10252214 .
• Thapa P, Nikam D, Das T, Sonawane G, Agarwal JP, Basu S . Oct 2015 . Clinical Efficacy and Safety Comparison of 177Lu-EDTMP with 153Sm-EDTMP on an Equidose Basis in Patients with Painful Skeletal Metastases . J Nucl Med . 56 . 10. 1513–9 . 10.2967/jnumed.115.155762 . 26315829 . free .
• 17401027 . 10.1200/JCO.2006.10.0123 . 25 . 10 . Bone marrow and not bone is the primary site for skeletal metastasis: critical role of [18F]fluorodeoxyglucose positron emission tomography in this setting . 2007 . J Clin Oncol . 1297; author reply 1297–9 . Basu S, Alavi A . free .
• 17709361 . 10.1259/bjr/53719785 . 80 . 957 . Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management . 2007 . Br J Radiol . 750–6 . Basu S, Nair N, Banavali S .
• Basu S, Ranade R, Thapa P . Jan 2016 . 177Lu-DOTATATE versus 177Lu-EDTMP versus cocktail/sequential therapy in bone-confined painful metastatic disease in medullary carcinoma of the thyroid and neuroendocrine tumour: can semiquantitative comparison of 68Ga-DOTATATE and 18F-fluoride PET-CT aid in personalized treatment decision making in selecting the best therapeutic option? . Nucl Med Commun . 37 . 1. 100–2 . 10.1097/mnm.0000000000000397 . 26587985 . 8869032 .
• Basu S, Parghane RV. "Designing and Developing PET-Based Precision Model in Thyroid Carcinoma: The Potential Avenues for a Personalized Clinical Care. PET Clin. 2017 Jan;12(1):27-37.
• Basu S, Ranade R, Ostwal V, Shrikhande SV . Jul 2016 . PET-Based Molecular Imaging in Designing Personalized Management Strategy in Gastroenteropancreatic Neuroendocrine Tumors . PET Clin. . 11 . 3. 233–41 . 10.1016/j.cpet.2016.02.004 . 27321028 .
• Basu S, Kwee TC, Gatenby R, Saboury B, Torigian DA, Alavi A . Jun 2011 . Evolving role of molecular imaging with PET in detecting and characterizing heterogeneity of cancer tissue at the primary and metastatic sites, a plausible explanation for failed attempts to cure malignant disorders . Eur J Nucl Med Mol Imaging . 38 . 6. 987–91 . 10.1007/s00259-011-1787-z . 21451997 . free .
• Rani D, Kaisar S, Awasare S, Kamaldeep Abhyankar A, Basu S . Sep 2014 . Examining recombinant human TSH primed ¹³¹I therapy protocol in patients with metastatic differentiated thyroid carcinoma: comparison with the traditional thyroid hormone withdrawal protocol . Eur J Nucl Med Mol Imaging . 41 . 9. 1767–80 . 10.1007/s00259-014-2737-3 . 24687139 . 33396401 .
• Basu S, Torigian D, Alavi A . Mar 2008 . Evolving concept of imaging bone marrow metastasis in the twenty-first century: critical role of FDG-PET . Eur J Nucl Med Mol Imaging . 35 . 3. 465–71 . 10.1007/s00259-007-0593-0 . 17955239 . 12675914 . free .
• Basu S, Kand P, Mallia M, Korde A, Shimpi H . Oct 2013 . Gratifying clinical experience with an indigenously formulated single-vial lyophilized HYNIC-TOC kit at the radiopharmaceutical division of BARC: a pivotal boost for building up a peptide receptor radionuclide therapy programme in an Indian setting . Eur J Nucl Med Mol Imaging . 40 . 10. 1622–4 . 10.1007/s00259-013-2501-0 . 23857460 . 36829829 .
• Basu S, Alavi A . Jan 2008 . Staging with PET and the "Will Rogers" effect: redefining prognosis and survival in patients with cancer . Eur J Nucl Med Mol Imaging . 35 . 1. 1–4 . 10.1007/s00259-007-0506-2 . 17828536 . 30453830 .
• Basu S, Alavi A . Apr 2007 . Defining co-related parameters between 'metabolic' flare and 'clinical', 'biochemical', and 'osteoblastic' flare and establishing guidelines for assessing response to treatment in cancer . Eur J Nucl Med Mol Imaging . 34 . 4. 441–3 . 10.1007/s00259-006-0264-6 . 17072613 . 5928921 .
• Basu S, Banerjee S . Feb 2017 . Developing a dedicated comprehensive α-radionuclide therapy program: should this be the vision of the atomic energy programs in the next decade? . Nucl Med Commun . 38 . 2. 103–105 . 10.1097/MNM.0000000000000626 . 27906780 . 1815387 .
• Basu S, Banerjee S . Jul 2017 . Envisaging an alpha therapy programme in the atomic energy establishments: the priorities and the nuances . Eur J Nucl Med Mol Imaging . 44 . 7. 1244–1246 . 10.1007/s00259-017-3686-4 . 28364163 . 3868711 .

See also

• Medical imaging
• Radiopharmaceuticals
• Fludeoxyglucose (18F)
• Standardized uptake value

Notes and References

1. Web site: View Bhatnagar Awardees . Shanti Swarup Bhatnagar Prize . 2016 . 12 November 2016.
2. Web site: HBNI Faculty . 2017 . Homi Bhabha National Institute.
3. Web site: Deans-Academic / Dean (Student's Affairs) . 2017 . Homi Bhabha National Institute.
4. Web site: Dr. Sandip Basu - VECC profile . 2017 . Variable Energy Cyclotron Centre.
5. Web site: Shanti Swaroop Bhatnagar Prize in Science & Technology 2012 . 2012 . Bhabha Atomic Research Centre.
6. Book: Søren Hess. Contribution of FDG to Modern Medicine, Part II, An Issue of PET Clinics. 27 December 2014. Elsevier Health Sciences. 978-0-323-34199-8. 12–.
7. Web site: Brief Profile of the Awardee . 2017 . Shanti Swarup Bhatnagar Prize.
8. Web site: On Google Scholar . 2017 . Google Scholar.
9. Web site: On ResearchGate . 2017 .
10. Book: Sandip Basu. Rakesh Kumar. Abass Alavi. Breast Cancer Imaging I: Number 3. 1 December 2009. W.B. Saunders Company. 9781437709643.
11. Book: Sandip Basu. Rakesh Kumar. Ayse Mavi, Abass Alavi. Breast Cancer Imaging II: Pet Clinics. 28 January 2010. Elsevier - Health Sciences Division. 978-1-4377-1402-9.
12. Book: Roger M. Macklis. Sushil Beriwal. Sandip Basu. Radiation Therapy Planning with PET: Number 2. 13 June 2011. W.B. Saunders Company.
13. Book: Babak Saboury. Abass Alavi. Mateen Moghbel, Sandip Basu. Modern Quantitative Techniques for PET. 2012. INTECH Open Access Publisher. 978-953-51-0359-2.
14. Book: Sandip Basu. Wei Chen. PET Imaging of Brain Tumors, An Issue of PET Clinics. 22 April 2013. Elsevier Health Sciences. 978-1-4557-7221-6.
15. Book: Sandip Basu. Abass Alavi. PET-Based Molecular Imaging in Evolving Personalized Management Design, An Issue of PET Clinics. 9 July 2016. Elsevier Health Sciences. 978-0-323-44871-0.
16. Book: Habib Zaidi. Thomas Kwee. Evolving Medical Imaging Techniques, An Issue of PET Clinics. 3 July 2013. Elsevier Health Sciences. 978-1-4557-7605-4. 14–.
17. Book: Rathan Subramaniam. Jorge Barrio. Novel Imaging Techniques in Neurodegenerative and Movement Disorders, An Issue of PET Clinics. 11 October 2013. Elsevier Health Sciences. 978-0-323-22736-0. 7–.
18. Book: Søren Hess. Contribution of FDG to Modern Medicine, Part I, An Issue of PET Clinics. 1 October 2014. Elsevier Health Sciences. 978-0-323-32627-8. 6–.
19. Web site: National Project Coordinator . 2017 . Bhabha Atomic Research Centre.
20. Web site: Editorial Board EJNMMI . 2017 . European Journal of Nuclear Medicine and Molecular Imaging.
21. Web site: Editorial Board NMC . 2017 . Nuclear Medicine Communications.
22. Web site: Editorial Board HJNM . 2017 . Hellenic journal of Nuclear Medicine.
23. Web site: 2012 Alavi-Mandell Awards . 2012 . Society of Nuclear Medicine and Molecular Imaging . 14.
24. Web site: Medical Sciences . 2017 . Council of Scientific and Industrial Research .