| Sancti-Spíritus | |
| Settlement Type: | Municipality |
| Pushpin Map: | Spain |
| Pushpin Mapsize: | 300 |
| Subdivision Type: | Country |
| Subdivision Name: |  Spain |
| Subdivision Type1: | Autonomous Community |
| Subdivision Type2: | Province |
| Subdivision Name2: | Salamanca |
| Subdivision Type3: | Comarca |
| Subdivision Name3: | Comarca de Ciudad Rodrigo |
| Subdivision Type4: | Subcomarca |
| Subdivision Name4: | Campo del Yeltes |
| Government Type: | Mayor–council |
| Governing Body: | Ayuntamiento de Sancti-Spíritus |
| Leader Party: | PP |
| Leader Title: | Mayor |
| Leader Name: | Bienvenido Garduño Sánchez |
| Area Footnotes: | [1] |
| Area Total Km2: | 142 |
| Elevation M: | 756 |
| Population Density Km2: | auto |
| Timezone1: | CET |
| Utc Offset1: | +1 |
| Timezone1 Dst: | CEST |
| Utc Offset1 Dst: | +2 |
| Coordinates: | 40.7053°N -6.4008°W |
| Postal Code Type: | Postcode |
| Postal Code: | 37470 |
Sancti-Spiritus is a municipality in the province of Salamanca, in the autonomous community of Castile-Leon, Spain. It is 70 km away from Salamanca, the capital of the province.It is situated 756 m above the sea level.
The area of the municipality is 142 km2 and it ranks 4th among the municipalities in the provinces of Salamanca after Ciudad Rodrigo, Castillejo de Martín Viejo, and Ledesma.
As of 2016 its population is 854 inhabitants and the postal code 37470.