| Official Name: | Sancti-Spíritus |
| Settlement Type: | Municipality |
| Pushpin Map: | Spain |
| Pushpin Map Caption: | Location in Spain |
| Coordinates: | 38.925°N -5.1472°W |
| Leader Title: | Alcalde |
| Leader Name: | Francisco Javier Sánchez Caballero |
| Area Total Km2: | 33.56 |
| Elevation M: | 485 |
| Population Density Km2: | auto |
| Utc Offset: | +1 |
| Utc Offset Dst: | +2 |
Sancti-Spíritus is a municipality in the province of Badajoz, Extremadura, Spain. According to the 2014 census,[1] the municipality has a population of 222 inhabitants.
A great part of the town's municipal term is submerged under the La Serena Reservoir, one of the largest in Spain.[2]