| San Sostene | |
| Official Name: | Comune di San Sostene |
| Coordinates: | 38.6375°N 16.4867°W |
| Province: | (CZ) |
| Mayor: | Luigi Aloisio |
| Area Total Km2: | 31 |
| Population Total: | 1329 |
| Population As Of: | 31 December 2013 |
| Population Demonym: | Sansostenesi |
| Elevation M: | 470 |
| Saint: | St. Sostenes |
| Postal Code: | 88060 |
| Area Code: | 0967 |
San Sostene (Calabrian: Sicilian: Sanzosti) is a village and comune in the province of Catanzaro in the Calabria region of southern Italy. It is one of the smallest comuni in the province. The town is bordered by Badolato, Brognaturo, Cardinale, Davoli, Isca sullo Ionio, Sant'Andrea Apostolo dello Ionio and Satriano.
The main economical activities in the comune include: