| San Secondo | |
| Settlement Type: | Frazione |
| Pushpin Map: | Italy |
| Coordinates: | 43.4011°N 12.2367°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Italy |
| Subdivision Type1: | Region |
| Subdivision Name1: | Umbria |
| Subdivision Type2: | Province |
| Subdivision Name2: | Perugia |
| Subdivision Type3: | Italian: [[Comune]] |
| Subdivision Name3: | Città di Castello |
| Elevation Footnotes: | [1] |
| Elevation M: | 271 |
| Population Total: | 980 |
| Population As Of: | 2001 |
| Timezone1: | CET |
| Utc Offset1: | +1 |
| Timezone1 Dst: | CEST |
| Utc Offset1 Dst: | +2 |
| Postal Code Type: | Postcode |
| Postal Code: | 06012 |
| Area Code: | 075 |
San Secondo (pronounced as /it/) is a frazione of the comune of Città di Castello in the Province of Perugia, Umbria, central Italy. It stands at an elevation of 271 metres above sea level. At the time of the Istat census of 2001 it had 980 inhabitants.