| San Sebastiano Curone | |
| Official Name: | Comune di San Sebastiano Curone |
| Coordinates: | 44.7833°N 13°W |
| Region: | Piedmont |
| Province: | Alessandria (AL) |
| Frazioni: | Marguata, Sant'Antonio, Telecco |
| Mayor: | Vincenzo Caprile |
| Area Total Km2: | 3.89 |
| Population Footnotes: | [1] |
| Population Total: | 571 |
| Population As Of: | 30 November 2017 |
| Population Demonym: | Sansebastianesi |
| Elevation M: | 342 |
| Saint: | St. Sebastian |
| Day: | January 20 |
| Postal Code: | 15056 |
| Area Code: | 0131 |
San Sebastiano Curone (Piedmontese: San Bastiau Curou) is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 110km (70miles) southeast of Turin and about 40km (30miles) southeast of Alessandria, at the confluence of the Curone and Museglia streams.
San Sebastiano Curone borders the following municipalities: Brignano-Frascata, Dernice, Gremiasco, and Montacuto.
Part of the commune of Fabbrica Curone it was under the dominations of the Malaspina and Fieschi from Genoa. In the 16th century, under the Doria, it became an important market centre for salt, fish and cereals.
It is the birthplace of Felice Giani, a neo-classicist painter.