| San Roque González de Santa Cruz | |
| Pushpin Map: | Paraguay |
| Subdivision Type: | Country |
| Subdivision Name: | Paraguay |
| Subdivision Type1: | Department |
| Subdivision Name1: | Paraguarí |
| Leader Title: | Intendente Municipal |
| Leader Name: | Del Pilar Cerafín Montiel Serna |
| Established Title: | Founded |
| Established Date: | 1538 |
| Founder: | Domingo Martínez de Irala |
| Population Total: | 11.648 (2008) |
| Area Total Km2: | 293 |
| Population Density Km2: | 40 |
| Postal Code Type: | Postal code |
| Area Code: | (595)(535) |
| Coordinates: | -25.883°N -57.283°W |
San Roque González de Santa Cruz is a distrito in the Paraguarí Department of Paraguay, it is located 97 km from Asunción, the capital of the country.
The National Route 1, crosses through this city.