| San Rafael | |
| Native Name: | Departamento San Rafael |
| Settlement Type: | Department |
| Coordinates: | -34.6167°N -87°W |
| Subdivision Type: | Country |
| Subdivision Name: | Argentina |
| Established Title: | Established |
| Established Date: | April 2, 1805 |
| Founder: | ? |
| Seat Type: | Seat |
| Seat: | San Rafael |
| Leader Title: | Mayor |
| Leader Name: | Omar Chafí Félix (PJ) |
| Unit Pref: | Metric |
| Area Total Km2: | 31,235 |
| Population Total: | 173,571 |
| Population Density Km2: | auto |
| Population Demonym: | sanrafaelina/o |
| Postal Code Type: | Postal Code |
| Postal Code: | M5600 |
| Postal2 Code Type: | IFAM |
| Postal2 Code: | MZA015 |
| Area Code Type: | Area Code |
| Area Code: | 02627 |
| Blank Name Sec1: | Patron saint |
| Blank Info Sec1: | San Rafael Arcángel |
San Rafael is one of the departments of Mendoza Province, Argentina. The seat of the department is in the city of San Rafael.
The department is subdivided in 18 districts: Ciudad, El Cerrito, Cuadro Nacional, Las Malvinas District, El Sosneado, Las Paredes, La Llave, Cuadro Benegas, Cuadro Nacional, Cañada Seca, Goudge, Jaime Prats, Monte Comán, Rama Caída, Real del Padre, Punta del Agua, Villa Atuel and Villa 25 de Mayo.