| San Polo Matese | |
| Official Name: | Comune di San Polo Matese |
| Coordinates: | 41.4667°N 44°W |
| Region: | Molise |
| Province: | Campobasso (CB) |
| Mayor: | Tonino Spina |
| Area Total Km2: | 17.7 |
| Population Footnotes: | [1] |
| Population Total: | 485 |
| Population As Of: | Dec. 2004 |
| Population Demonym: | Sanpolesi |
| Elevation M: | 751 |
| Saint: | St. Nicholas |
| Day: | 6 December |
| Postal Code: | 86020 |
| Area Code: | 0874 |
San Polo Matese is a comune (municipality) in the Province of Campobasso in the Italian region Molise, located about 20km (10miles) southwest of Campobasso.
San Polo Matese borders the following municipalities: Bojano, Campochiaro, Colle d'Anchise, San Gregorio Matese.