| San Piero a Sieve | |
| Coordinates: | 43.96°N 11.3217°W |
| Region: | Tuscany |
| Province: | Florence (FI) |
| Comune: | Scarperia e San Piero |
| Population Total: | 2857 |
| Population Demonym: | Sanpierini |
| Elevation M: | 212 |
| Saint: | St. Peter |
| Day: | 29 June |
| Postal Code: | 50037 |
| Area Code: | 055 |
San Piero a Sieve is a frazione of the comune (municipality) of Scarperia e San Piero, located in the Metropolitan City of Florence, in Tuscany, Italy, about 20km (10miles) north of Florence. It was an independent comune until 1 January 2014.
The Medici Villa del Trebbio is located within the territory of San Piero.