| San Pedro y San Pablo Asistencia | |
| Location: | Pacifica, California |
| Originalname: | Asistencia de la Misión San Francisco de Asís |
| Translation: | Sub-Mission of the Mission San Francisco de Asís |
| Namesake: | Saint Peter and Saint Paul |
| Founded: | 1786 |
| Militarydistrict: | Fourth |
| Nativetribe: | Ohlone Costanoan |
| Placename: | Pruristac |
| Owner: | County of San Mateo |
| Currentuse: | Museum |
| Coordinates: | 37.5872°N -122.4933°W |
| Designation1: | NRHP |
| Designation1 Date: | 1976 |
| Designation1 Partof: | Sánchez Adobe |
| Designation1 Number: |
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| Designation2: | California |
| Designation2 Date: | 1947 |
| Designation2 Partof: | Sánchez Adobe |
| Designation2 Number: |
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The San Pedro y San Pablo Asistencia is an asistencia or "sub-mission" to Mission San Francisco de Asís in the San Pedro Valley in Pacifica, California. Established in 1786 at the Ohlone village of Pruristac, the site is located within the bounds of the Rancho San Pedro (home to the Sánchez Adobe).
Within the first year a chapel, granary, tack room, and three other rooms had been constructed, using native labor. In 1788 two more rooms were added. In 1789 a second granary was built, quarters for the mayordomo, and quarters for the missionaries were built. Also, a covered passageway which temporarily served as a kitchen. Crops of wheat and beans were planted and limestone was mined at nearby Mori Point in quantities to provide for the food and construction needs of the parent mission. At its peak the asistencia consisted of a three-wing main structure surrounding a central plaza. Corn, peas, barley, asparagus, and rosemary would, in time also be cultivated, along with grape vineyards and groves of peach and quince trees. Due to a significant decline in the native population due to several infectious diseases including syphilis (Stanger 1963), the population dropped from 300 in 1790 to 25 in 1792 at which point the facility was closed and used mainly as an outpost to graze cattle after 1790.
After secularization of the missions in 1834, Juan Alvarado, the Mexican Governor of California, granted the lands of the 8926acres Rancho San Pedro to Francisco Sanchez in 1839. Included were all of the buildings of the Asistencia. Sanchez retained ownership of the property after California was ceded to the United States in 1848. In 1894, roof tiles were salvaged from the property and installed on the Southern Pacific Railroad depot located in Burlingame, California (the first permanent structure constructed in the Mission Revival Style). Today, little remains of the original installation.