| San Nicola Manfredi | |
| Official Name: | Comune di San Nicola Manfredi |
| Coordinates: | 41.0667°N 63°W |
| Region: | Campania |
| Province: | Benevento (BN) |
| Mayor: | Fernando Errico |
| Area Total Km2: | 18.9 |
| Population Total: | 3716 |
| Population As Of: | 1 January 2015[1] |
| Population Demonym: | Sannicolesi |
| Elevation M: | 450 |
| Postal Code: | 82010 |
| Area Code: | 0824 |
San Nicola Manfredi is a comune (municipality) in the Province of Benevento in the Italian region Campania, located about 50 km northeast of Naples and about 8 km southeast of Benevento.
San Nicola Manfredi borders the following municipalities: Benevento, Ceppaloni, Chianche, Montefusco, Paduli, Petruro Irpino, San Giorgio del Sannio, San Martino Sannita, Sant'Angelo a Cupolo, Torrioni.