| San Michele di Serino | |
| Official Name: | Comune di San Michele di Serino |
| Coordinates: | 40.8833°N 65°W |
| Province: | (AV) |
| Mayor: | Michele Boccia |
| Area Total Km2: | 4.47 |
| Population Footnotes: | [1] |
| Population Total: | 2602 |
| Population As Of: | 31 December 2010 |
| Population Demonym: | Sammichelesi |
| Elevation M: | 364 |
| Saint: | St. Michael Archangel |
| Day: | 29 September |
| Postal Code: | 83020 |
| Area Code: | 0825 |
San Michele di Serino is a town and comune in the province of Avellino, Campania, southern Italy.