| San Michele Salentino | |
| Official Name: | Comune di San Michele Salentino |
| Shield Alt: | Coat of arms of San Michele Salentino |
| Pushpin Label Position: | left |
| Coordinates: | 40.6333°N 55°W |
| Province: | (BR) |
| Frazioni: | Borgata Ajeni |
| Mayor: | Giovanni Allegrini |
| Area Total Km2: | 26 |
| Population Footnotes: | [1] |
| Population Total: | 6372 |
| Population As Of: | 31 December 2010 |
| Population Demonym: | Sammichelani |
| Elevation M: | 153 |
| Saint: | St. Michael Archangel |
| Day: | 29 September |
| Postal Code: | 72018 |
| Area Code: | 0831 |
San Michele Salentino is a comune in the province of Brindisi in Apulia, on the south-east Italian coast. Its main economic activities are the growing of olives and grapes.
See also: List of twin towns and sister cities in Italy. San Michele Salentino is twinned with:
Monte Sant'Angelo, Italy (since 2007)