| San Marcos, Antioquia | |
| Settlement Type: | Municipality and town |
| Mapsize: | 250px |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Colombia |
| Subdivision Type: | Country |
| Subdivision Type1: | Department |
| Subdivision Name1: | Antioquia Department |
| Timezone: | Colombia Standard Time |
| Utc Offset: | -5 |
San Marcos is a town in Antioquia department in Colombia. It is approximately 175 miles (282 km) north of Medellín, in the heart of Colombia's coffee-growing region.
San Marcos is located at . The symbol for its airport is SRS.