| San Luis de la Reina | |
| Settlement Type: | Municipality |
| Mapsize: | 150 |
| Pushpin Map: | El Salvador |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in El Salvador |
| Subdivision Type: | Country |
| Subdivision Name: |  El Salvador |
| Subdivision Type1: | Department |
| Subdivision Name1: | San Miguel Department |
| Established Title: | Established |
| Established Date: | 1811 |
| Unit Pref: | Imperial |
| Area Total Km2: | 168.2 |
| Coordinates: | 13.8167°N -109°W |
| Elevation M: | 527 |
San Luis de la Reina (Saint Louis of the Queen) is a municipality in the San Miguel department of El Salvador. San Luis is an ecotourist destination.[1]
In the late 18th century, the Ostucal Hacienda (Ostucal is Nawat for "houses in the ravine") was owned by the parish of Osicala. It produced indigo, cereals, and raised cattle. In 1811, it was constructed into and raised to a city; patronal festivals are held on 24 and 25 August.[1]