| San Luis | |
| Native Name Lang: | es |
| Settlement Type: | City |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of San Luis in Argentina |
| Coordinates: | -33.3°N -86°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Type2: | Department |
| Subdivision Name2: | Juan Martín de Pueyrredón |
| Established Title: | Founded |
| Established Date: | August 25, 1594 |
| Leader Party: | Avanzar San Luis |
| Leader Title: | Intendant |
| Leader Name: | Gastón Hissa |
| Unit Pref: | Metric |
| Elevation M: | 709 |
| Population Total: | 169,947 |
| Population As Of: | 2010 census |
| Population Density Km2: | auto |
| Population Demonym: | puntano/a |
| Timezone1: | ART |
| Utc Offset1: | −3 |
| Postal Code Type: | CPA base |
| Postal Code: | D5700 |
| Area Code Type: | Dialing code |
| Area Code: | +54 0266 |
San Luis (pronounced as /es/) is the capital city of San Luis Province in the Cuyo region of Argentina. It is also the seat of the Juan Martín de Pueyrredón Department.
Points of interest in the city include the Park of the Nations, the neoclassical cathedral, a number of museums, including the Dora Ochoa De Masramón Provincial Museum, and examples of colonial architecture. A number of landmarks honour the Argentine War of Independence, as well. Independence Park features an equestrian monument to General José de San Martín, liberator of Argentina, Chile and Perú. Nearby Pringles Plaza honours Colonel Juan Pascual Pringles, one of San Martín's chief adjutants and, briefly, Governor of San Luis Province.
Fishing in the nearby Lake Potrero de los Funes, and other locations, is also popular. The Sierra de las Quijadas National Park is located from the city.
National Route 7 connects San Luis to Mendoza, to the west, and Buenos Aires, to the east. San Luis Airport is located less than north of the city centre, and has regular flights to Buenos Aires.
San Luis was founded on August 25, 1594, by Luis Jufré de Loaysa y Meneses. The settlement was later abandoned, and was reestablished in 1632 by Martín García Oñez de Loyola as San Luis de Loyola Nueva Medina de Río Seco.
By the end of the 19th century, San Luis had 7,000 inhabitants, and in 1882 the Argentine Great Western Railway reached the city on its way to Chile. The following year, work began on the cathedral. The Governor's Executive Building, designed in French renaissance architecture, was completed in 1911. The city's population reached 40,000 in 1960, and grew rapidly afterwards, when light industry and growing numbers of retirees began to migrate to the area; at the, its population was 153,322.
Because the city is located at the part of the Sierras Grandes known as Punta de los Venados (Deer Point), the inhabitants of the city are called puntanos.
San Luis lies at the foot of the Sierras Grandes, along the northern bank of the Chorrillos River, and is set on a dry pampas plateau, around above sea level.
San Luis has a humid subtropical climate (Cwa, according to the Köppen climate classification) and it closely borders a semi-arid climate (BSk). Summers are hot and humid, and winters are cool and dry, with temperatures falling below 0C sometimes and snowfalls can occur occasionally. The hottest month, January, has an average temperature of 24C, and the coldest month, July, has an average of 8.9C. The annual average temperature is 17.4C.