| San Luis de Palenque | |
| Settlement Type: | Municipality and town |
| Mapsize: | 250px |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Colombia |
| Subdivision Type: | Country |
| Subdivision Name: |  Colombia |
| Subdivision Type1: | Department |
| Subdivision Name1: | Casanare Department |
| Timezone: | Colombia Standard Time |
| Utc Offset: | -5 |
| Elevation Ft: | 550 |
San Luis de Palenque is a town and municipality in the Department of Casanare, Colombia. The town is on a bend of the Pauto River, a tributary of the Meta River.
It is served by San Luis de Palenque Airport.