| San Luis de Gaceno | |
| Settlement Type: | Municipality and town |
| Mapsize: | 250px |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Colombia |
| Subdivision Type: | Country |
| Subdivision Type1: | Department |
| Subdivision Name1: | Boyacá Department |
| Subdivision Type2: | Province |
| Subdivision Name2: | Neira Province |
| Leader Title: | Mayor |
| Leader Name: | Juan Carlos Buitrago Salgado |
| Timezone: | Colombia Standard Time |
| Utc Offset: | -5 |
| Elevation M: | 395 |
San Luis de Gaceno (pronounced as /es/) is a town and municipality in Boyacá Department, Colombia, part of the subregion of the Neira Province.