| Official Name: | San Luis |
| Pushpin Map: | Honduras |
| Subdivision Type: | Country |
| Subdivision Type1: | Department |
| Subdivision Name1: | Comayagua |
| Area Total Km2: | 122 |
| Population As Of: | 2015 |
| Settlement Type: | Municipality |
| Population Total: | 11404 |
| Population Density Km2: | auto |
| Coordinates: | 14.75°N -112°W |
San Luis is a municipality in the Honduran department of Comayagua.
On November 24, 2013, the Liberal Party candidate and the National Party candidate were tied for the mayoralty of San Luis, Comayagua. Since then and in the inauguration of the actual period (on January 25, 2014), there has been no mayor.