| San Lorenzo Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Pushpin Map Caption: | Location of San Lorenzo Department in Argentina |
| Coordinates: | -27.2833°N -85°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Chaco Province |
| Seat Type: | Head town |
| Seat: | Villa Berthet |
| Unit Pref: | Metric |
| Area Total Km2: | 2,135 |
| Population Total: | 14,252 |
| Population Density Km2: | auto |
| Population Demonym: | Sanlorenzense |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code: | H3545 |
| Area Code: | 03735 |
San Lorenzo is a department of Chaco Province in Argentina.
The provincial subdivision has a population of about 14,000 inhabitants in an area of 2135km², and its capital city is Villa Berthet, which is located around 1190km (740miles) from the Capital federal.