San Lorenzo (or: Villa San Lorenzo) is a town in the Tarija Department in Bolivia.
San Lorenzo is the administrative center of Eustaquio Méndez Province and situated at -21.4167°N -64.7494°W, 2,001 m above sea level, on the left bank of Río Calama, 15 km north of Tarija, the department capital.
San Lorenzo had a population of 2,340 inhabitants according to the 1992 (census), 2,754 inhabitants according to the 2001 census, and was predicted to have more than 3,000 inhabitants by 2007.
San Lorenzo was the home of Eustaquio Méndez, one of the leaders in the fights for the Argentina independence. The local museum Casa del Moto Méndez exhibits some of his personal belongings and weapons.