| Official Name: | San Juan Nepomuceno |
| Settlement Type: | City |
| Pushpin Map: | Paraguay |
| Subdivision Type: | Country |
| Subdivision Name: |  Paraguay |
| Subdivision Type1: | Department |
| Subdivision Name1: | Caazapá |
| Leader Title: | Intendente Municipal |
| Leader Name: | Oscar Derlis Molinas Ruíz (ANR-HC) |
| Established Title: | Founded |
| Established Date: | November 20, 1797 for Lázaro de Rivera y Espinosa |
| Area Total Km2: | 1011 |
| Population As Of: | 2002 |
| Population Total: | 24243 |
| Population Density Km2: | auto |
| Timezone1: | AST |
| Utc Offset1: | -04 |
| Timezone1 Dst: | ADT |
| Utc Offset1 Dst: | -03 |
| Coordinates: | -26.1167°N -55.93°W |
| Postal Code Type: | Postal code |
| Postal Code: | 5880 |
| Area Code: | (595) (544) |
San Juan Nepomuceno is a city and district in the Paraguayan department of Caazapá. It has the largest urban conglomeration of the department.
It lies 249 km southeast of the national capital city, Asuncion, at the terminus of the Blas Garay highway. Blas Garay is a spur of the national highway Number 8 and forks at a crossroads near the town of Ñumí. This district is located in the east of the department and shares borders with six districts of Caazapá (clockwise: N: General Higinio Morínigo, Abaí; E: Tavaí; S: Yuty; W: Buena Vista, Caazapá) and one of the Itapúa (Alto Verá).
According to the 2002 Census this district has the largest urban area of Caazapá with 6937 inhabitants in its urban conglomeration. Its total population is the third in the department, with 24,243 inhabitants, after Yuty and Abaí.