| San Isidro | |
| Settlement Type: | Municipality |
| Pushpin Map: | Nicaragua |
| Pushpin Label Position: | right |
| Pushpin Mapsize: | 250 |
| Pushpin Map Caption: | Location in Nicaragua |
| Subdivision Type: | Country |
| Subdivision Name: |  Nicaragua |
| Subdivision Type1: | Department |
| Subdivision Name1: | Matagalpa |
| Unit Pref: | Imperial |
| Area Total Km2: | 283 |
| Population As Of: | 2005 |
| Population Total: | 17412 |
| Population Density Km2: | auto |
| Population Urban: | 8015 |
| Coordinates: | 12.9333°N -98°W |
| Blank Name: | Climate |
| Blank Info: | Aw |
San Isidro (pronounced as /es/) is a municipality in the Matagalpa department of Nicaragua.[1]