| Official Name: | San Francisco Zapotitlán |
| Settlement Type: | Municipality |
| Pushpin Map: | Guatemala |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Guatemala |
| Subdivision Type: | Country |
| Subdivision Name: | Guatemala |
| Subdivision Name1: | Suchitepéquez Department |
| Leader Title: | Mayor |
| Unit Pref: | Imperial |
| Area Total Km2: | 45.8 |
| Population As Of: | 2018 census |
| Population Footnotes: | [1] |
| Population Total: | 22533 |
| Population Density Km2: | auto |
| Population Blank2 Title: | Religions |
San Francisco Zapotitlán (pronounced as /es/) is a town, with a population of 18,468 (2018 census),[2] and a municipality in the Suchitepéquez department of Guatemala.