| San Fernando Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Pushpin Map Caption: | Location of San Fernando Department in Argentina |
| Coordinates: | -27.45°N -117°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Chaco Province |
| Established Date: | 1878 (Resistencia) |
| Seat Type: | Head town |
| Seat: | Resistencia |
| Unit Pref: | Metric |
| Area Total Km2: | 3,489 |
| Population Total: | 365,637 |
| Population Density Km2: | auto |
| Population Demonym: | Sanfernandense |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code: | H3500 |
| Area Code: | 03722 |
| Website: | http://www.resistencia.gov.ar/ |
San Fernando is a department of Chaco Province in Argentina.
The provincial subdivision has a population of about 365,000 inhabitants in an area of 3,489 km2, and its capital city is Resistencia, which is also the provincial capital. It located around 1,020 km from the Capital federal.
The department consists of 5 first-level municipalities: