| San Donato di Lecce | |
| Official Name: | Comune di San Donato di Lecce |
| Shield Alt: | Coat of arms |
| Pushpin Label Position: | left |
| Coordinates: | 40.2667°N 29°W |
| Province: | (LE) |
| Frazioni: | Galugnano |
| Area Total Km2: | 21 |
| Population Footnotes: | [1] |
| Population Total: | 5863 |
| Population As Of: | November 2008 |
| Elevation M: | 70 |
| Saint: | San Donato |
| Day: | 7 August |
| Postal Code: | 73010 |
| Area Code: | 0832 |
| Istat: | 075069 |
| Fractions: | Caprarica di Lecce, Cavallino, Lequile, San Cesario di Lecce, Soleto, Sternatia |
| Fiscal Code: | H826 |
San Donato di Lecce is a town and comune of 5,837 inhabitants in the Italian province of Lecce in the Apulia region of south-east Italy. It includes the frazione of Galugnano.