| San Donaci | |
| Official Name: | Comune di San Donaci |
| Shield Alt: | Coat of arms of San Donaci |
| Pushpin Label Position: | left |
| Coordinates: | 40.45°N 72°W |
| Region: | Apulia |
| Province: | (BR) |
| Mayor: | Angelo Marasco |
| Area Total Km2: | 34.04 |
| Population Footnotes: | [1] |
| Population Total: | 6768 |
| Population As Of: | 31 December 2015 |
| Population Demonym: | Sandonacesi |
| Elevation M: | 42 |
| Saint: | Santa Maria |
| Day: | 5 August |
| Postal Code: | 72025 |
| Area Code: | 0831 |
San Donaci is a comune in the province of Brindisi in Apulia, on the southeast coast of Italy. Its main economic activities are tourism and the growing of olives and grapes.