| San Cosme Department | |
| Native Name: | Departamento San Cosme |
| Settlement Type: | Department |
| Coordinates: | -27.5167°N -92°W |
| Subdivision Type: | Country |
| Subdivision Name: | Argentina |
| Established Title: | Established |
| Seat Type: | Seat |
| Seat: | San Cosme |
| Leader Title: | Mayor |
| Unit Pref: | Metric |
| Area Total Km2: | 595 |
| Population Total: | 13,189 |
| Population Density Km2: | auto |
| Postal Code Type: | Postal Code |
| Postal Code: | W3420 |
| Area Code Type: | Area Code |
| Area Code: | 03783 |
San Cosme Department is a department of Corrientes Province in Argentina.
The provincial subdivision has a population of about 13,189 inhabitants in an area of, and its capital city is San Cosme.