| San Carlos | |
| Native Name: | Departamento San Carlos |
| Settlement Type: | Department |
| Coordinates: | -33.7667°N -71°W |
| Subdivision Type: | Country |
| Subdivision Name: | Argentina |
| Established Title: | Established |
| Established Date: | November 4, 1772 |
| Founder: | ? |
| Seat Type: | Seat |
| Seat: | San Carlos |
| Leader Title: | Mayor |
| Leader Name: | Alejandro Morillas |
| Unit Pref: | Metric |
| Area Total Km2: | 11,578 |
| Population Total: | 28,341 |
| Population Density Km2: | auto |
| Population Demonym: | sancarlino/a |
| Postal Code Type: | Postal Code |
| Postal Code: | M5569 |
| Postal2 Code Type: | IFAM |
| Postal2 Code: | MZA013 |
| Area Code Type: | Area Code |
| Area Code: | 02622 |
| Blank Name Sec1: | Patron saint |
| Blank Info Sec1: | ? |
| Website: | no |
San Carlos is a western department of Mendoza Province in Argentina.
The provincial subdivision has a population of about 28,000 inhabitants in an area of, and its capital city is San Carlos, which is located around from the Capital federal.