| San Antonio de Oriente | |
| Settlement Type: | Municipality |
| Pushpin Map: | Honduras |
| Pushpin Label Position: | left |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Honduras |
| Subdivision Type: | Country |
| Subdivision Name: |  Honduras |
| Subdivision Type1: | Department |
| Subdivision Name1: | Francisco Morazán |
| Established Title: | Founded |
| Established Date: | 1660 |
| Area Total Km2: | 227 |
| Population As Of: | 2015 |
| Population Total: | 15299 |
| Population Density Km2: | auto |
| Population Blank1 Title: | Ethnicities |
| Coordinates: | 14.0333°N -90°W |
| Elevation M: | 1173 |
San Antonio de Oriente is a municipality in the Honduran department of Francisco Morazán.
Population as of 2015 is 15,299.[1] The first occupants came in 1660 in the village Mineral de San Antonio that is 4 km away from the present town. Nowadays it is called San Antonio Yusguare. A kilometre west of San Antonio de Oriente lies San Antonio Ocidente. San Antonio de Oriente lies 28 km from Tegucigalpa, high in the mountains. The Santa Iné River crosses the municipality in a south to north direction. There is a school and a health centre. Many youngsters from the village have left to go to Tegucigalpa to study.
Florencio Xatruch (1811 - 1893) a General who led the Honduran expeditionary force against William Walker in Nicaragua in 1856 was born in the town.