| Official Name: | San Antonio de los Cobres |
| Pushpin Map: | Argentina |
| Subdivision Type: | Country |
| Subdivision Type1: | Province |
| Subdivision Type2: | Department |
| Subdivision Name: |  Argentina |
| Subdivision Name2: | Los Andes |
| Leader Title: | Mayor |
| Leader Name: | Guzmán Viveros |
| Established Title: | Established |
| Established Date: | ? |
| Population As Of: | 2001 |
| Population Total: | 5,482 |
| Timezone1: | ART |
| Utc Offset1: | −3 |
| Coordinates: | -24.2178°N -66.32°W |
| Elevation M: | 3775 |
| Postal Code Type: | Postal code |
| Postal Code: | A4411 |
| Blank Name: | Climate |
| Blank Info: | BWk |
San Antonio de los Cobres is a small town of population 5,482 (per the 2001 INDEC census)[1] in northwestern Argentina. It is the capital of the Los Andes Department of the Salta Province.[2]
The town is known for its high elevation of approximately 3775abbr=offNaNabbr=off above sea level, being one of the highest elevations of any city or town in Argentina.[2] It is located approximately 160km (100miles) from the city of Salta and 2000km (1,000miles) from the capital, Buenos Aires.[2] It is part of the Andes desert and described to be an arid region with few trees and scarce drinking water.
In a 2015 podcast from The Naked Scientists, research has shown that people in the San Antonio de los Cobres area have remarkably developed a mutation in their genes to cope with the high levels of arsenic in the area. Having concentrations about ten times higher that those deemed safe by the World Health Organization (WHO), naturally occurring arsenic has created a very toxic environment in this region contaminating the water supplies. Evolutionary processes resulting from long term exposure have caused a specific mutation within the DNA of this population allowing them to process arsenic more quickly throughout their systems and preventing the formation of poisonous byproducts that would normally form within the body with exposure to the element. This is the first adaptation in humans regarding a toxic chemical to ever be documented.[3]
San Antonio de las Cobres takes its name from the nearby Sierra de Cobre, or Copper Mountain, which is rich in that mineral. Economic activity in the town is based on mining of the mineral-rich surrounding mountains, and weaving using local llama wool.[4] The town is also a stop along the Tren a las Nubes (Train of the Clouds),[4] on the Salta-Antofagasta rail line.
San Antonio de los Cobres has a cool arid climate (Köppen BWk) characterised by mild summers, cold, bone-dry winters, and very large diurnal temperature variation due to the extreme altitude. Rainfall is essentially nil except from January to March, when 96mm of an annual total of 104mm falls from thunderstorms.