| San Antonio de Esquilache District | |
| Native Name Lang: | es |
| Settlement Type: | District |
| Mapsize: | frameless |
| Subdivision Type: | Country |
| Subdivision Name: |  Peru |
| Subdivision Type1: | Region |
| Subdivision Name1: | Puno |
| Subdivision Type2: | Province |
| Subdivision Name2: | Puno |
| Parts Type: | Subdivisions |
| Parts Style: | para |
| Established Title: | Founded |
| Seat Type: | Capital |
| Seat: | San Antonio de Esquilache |
| Leader Title: | Mayor |
| Leader Name: | Teodoro Cipriano Ticona Alvarez |
| Unit Pref: | Metric |
| Area Total Km2: | 376.75 |
| Elevation M: | 4700 |
| Population Total: | 1613 |
| Population As Of: | 2005 census |
| Population Density Km2: | auto |
| Timezone1: | PET |
| Utc Offset1: | -5 |
| Blank Name Sec1: | UBIGEO |
| Blank Info Sec1: | 210113 |
San Antonio District or San Antonio de Esquilache District is one of fifteen districts of the Puno Province in the Puno Region of Peru.[1]
Some of the highest mountains of the district are listed below:[2]
The people in the district are mainly indigenous citizens of Quechua descent. Quechua is the language which the majority of the population (85.94%) learnt to speak in childhood, 8.60% of the residents started speaking using the Aymara language and 5.46% learnt Spanish as the first language (2007 Peru Census).[3]