| San Antonio | |
| Native Name Lang: | es |
| Settlement Type: | Locality and municipality |
| Pushpin Map: | Argentina Misiones Province#Argentina |
| Pushpin Map Caption: | Location of the San Antonio in Misiones Province and Argentina |
| Coordinates: | -26.0593°N -53.732°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Type2: | Department |
| Subdivision Name2: | General Manuel Belgrano |
| Established Title: | Foundation |
| Unit Pref: | Metric |
| Population Footnotes: | [1] |
| Population Total: | 3665 |
| Population As Of: | 2010 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Area Code Type: | Dialing code |
San Antonio is a city in the north-eastern region of Misiones Province, Argentina, and the capital of the General Manuel Belgrano Department. It lies on the Brazilian border at -26.05°N -96°W. Its population was 3,665 at the 2010 census (INDEC).
The municipality contains part of the Urugua-í Provincial Park, created in 1990.