| San Andrés de Giles | |
| Native Name: | Partido de San Andrés de Giles |
| Settlement Type: | Department |
| Image Blank Emblem: | San andres giles logo.png |
| Blank Emblem Size: | 100 |
| Coordinates: | -34.4333°N -85°W |
| Subdivision Type: | Country |
| Subdivision Name: | Argentina |
| Established Title: | Established |
| Established Date: | November 30, 1806 |
| Founder: | Presbítero Vicente Piñero |
| Seat Type: | Seat |
| Seat: | San Andrés de Giles |
| Leader Party: | UNA |
| Leader Title: | Mayor |
| Leader Name: | Carlos Puglelli |
| Unit Pref: | Metric |
| Area Total Km2: | 1135 |
| Population Total: | 23027 |
| Population Density Km2: | auto |
| Population Demonym: | gilense |
| Postal Code Type: | Postal Code |
| Postal Code: | B6720 |
| Postal2 Code Type: | IFAM |
| Postal2 Code: | BUE111 |
| Area Code Type: | Area Code |
| Area Code: | 02325 |
| Blank Name Sec1: | Patron saint |
| Blank Info Sec1: | San Andrés Apóstol |
San Andres de Giles Partido is a partido of Buenos Aires Province in Argentina. The capital of the partido is San Andrés de Giles, west of Buenos Aires and west of the provincial capital La Plata. The provincial subdivision has a population of 20,829 inhabitants (2001) in an area of .
It is bordered by Exaltación de la Cruz in the northeast, Mercedes in the south, Luján in the southeast, Suipacha in the southeast, Carmen de Areco in the east and San Antonio de Areco in the northeast.