| Samuel Walker | |
| Order: | 3rd |
| Office: | Mayor of Roxbury, Massachusetts |
| Term Start: | August 11, 1851 |
| Term End: | 1853 |
| Predecessor: | Henry A. S. Dearborn |
| Successor: | Linus Bacon Comins |
| Birth Date: | October 9, 1793 |
| Birth Place: | England |
| Death Date: | December 11, 1860 |
| Death Place: | Roxbury, Massachusetts |
| Nationality: | American |
| Children: | E. C. R. Walker |
| Profession: | Publisher |
Samuel Walker (October 9, 1793 – December 11, 1860) was an American politician, who served as the third Mayor of Roxbury, Massachusetts from 1851 to 1853. Walker was also the fifth President of the Massachusetts Horticultural Society.