| Samuel Wolfson School for Advanced International Studies and Leadership | |
| Motto: | "Committed to Excellence" |
| Streetaddress: | 7000 Powers Avenue Jacksonville, Florida, USA 32217 |
| Established: | 1965 |
| Type: | Magnet School |
| District: | Duval County Public Schools |
| Principal: | Christopher Begley January 16, 2017(present) |
| Grades: | 9–12 |
| Enrollment: | 922 (2022-23)[1] |
| Teaching Staff: | 48.00 (FTE) |
| Ratio: | 19.21 |
| Campus Type: | Suburban |
| Campus Size: | 35.42acres |
| Mascot: | Wolfpack |
| Newspaper: | Wolf News |
| Website: | Wolfson High School |
| Colors: | Scarlet Red, White & Blue |
| Country: | USA |
| Coordinates: | 30.2509°N -81.6158°W |
Samuel W. Wolfson High School (or simply Wolfson) is a magnet high school located in the Duval County Public School district. As an academic magnet and college preparatory school, Wolfson specializes in Advanced Placement and International Baccalaureate courses. In addition to its academic focus, Samuel Wolfson School for Advanced Studies has a athletics program, a program for visual and performing arts, and a JROTC program. Its name is derived from Samuel W. Wolfson, a local businessman whose family was prominent in Jacksonville, Wolfson houses the Finance, Law, and Business magnet program. A VyStar Credit Union branch is located inside the school, and is available for students and faculty to use. Wolfson is a member of the International Baccalaureate Diploma Programme. The school's main rival is the Englewood Rams.
The school is notable for its diverse[2] student body. Students represent many foreign countries including Bosnia and Herzegovina, Albania, and Lebanon, among others. In addition, Wolfson's magnet program allows students from all over the district to attend via the AP program and the IB program.