Samuel Rexford (October 14, 1776 Claverack, then in Albany Co., now in Columbia County, New York - February 24, 1857 Lock Haven, Clinton County, Pennsylvania) was an American politician from New York.
He was in the lumber business. He was Supervisor of the Town of Sidney in 1826 and 1827.
He was a member of the New York State Assembly (Delaware Co.) in 1823.
He was a member of the New York State Senate (2nd D.) from 1829 to 1832, sitting in the 52nd, 53rd, 54th and 55th New York State Legislatures.