| Samuel Jones Nicholls | |
| Birth Date: | 7 May 1885 |
| Birth Place: | Spartanburg, South Carolina |
| Death Place: | Spartanburg, South Carolina |
| Resting Place: | Spartanburg, South Carolina |
| State: | South Carolina |
| District: | 4th |
| Term Start: | September 14, 1915 |
| Term End: | March 3, 1921 |
| Predecessor: | Joseph T. Johnson |
| Successor: | John J. McSwain |
| Office2: | Member of the South Carolina House of Representatives from Spartanburg County |
| Term2: | January 8, 1907 - February 12, 1909 |
| Party: | Democratic |
| Alma Mater: | Wofford College Virginia Polytechnic Institute University of Chicago Law School |
| Branch: | South Carolina National Guard |
| Rank: | Captain |
| Commands: | Company I, First Infantry Regiment |
Samuel Jones Nicholls (May 7, 1885 – November 23, 1937) was a United States representative from South Carolina. He was born in Spartanburg, South Carolina. He attended Bingham Military Institute in Asheville, North Carolina; Wofford College, in Spartanburg, South Carolina; Virginia Polytechnic Institute in Blacksburg, Virginia; and the University of Chicago Law School. He was admitted to the bar in 1906 and commenced practice in Spartanburg.
Nicholls was the city attorney of Spartanburg and prosecuting attorney of Spartanburg County, South Carolina. He was a member of the South Carolina House of Representatives 1907-1908. He served by special appointment as circuit judge and as associate justice of the Supreme Court of South Carolina. He also organized and was captain for three years of Company I, First Regiment, South Carolina National Guard Infantry.
Nicholls was elected as a Democrat to the Sixty-fourth Congress to fill the vacancy caused by the resignation of Joseph T. Johnson. He was reelected to the Sixty-fifth and Sixty-sixth Congresses and served from September 14, 1915 to March 3, 1921 and declined to be a candidate for renomination in 1920. He resumed the practice of law in Spartanburg, South Carolina until his death there on November 23, 1937. He is buried in West Oakwood Cemetery.