| Office: | 8th Assistant Secretary of State for International Organization Affairs |
| Term Start: | February 11, 1969 |
| Term End: | June 20, 1973 |
| Preceded: | Joseph John Sisco |
| Succeeded: | David H. Popper |
| Birth Date: | June 22, 1918 |
| Death Date: | March 21, 2002 |
| Birth Place: | Rochester, New York |
| Education: | University of Rochester |
Samuel De Palma (June 22, 1918 – March 21, 2002) was an official in the United States Department of State.
De Palma was born in Rochester, New York. He was educated at the University of Rochester, graduating in 1940. After college, he took a job with the United States Department of War in Washington, D.C. as a civilian economic analyst and intelligence specialist.
After World War II, in 1945, De Palma joined the United States Foreign Service. In 1949, he was a member of the United States Department of State's Bureau of International Organization Affairs working at the United Nations until 1952. In 1956, he became deputy director of the United Nations Office of Political and Security Affairs. He then spent a year at the National War College. He moved to Paris in 1961, becoming first secretary and political office at NATO. From 1961 to 1963, he worked at the U.S. embassy in the Netherlands. He joined the Arms Control and Disarmament Agency in 1963, becoming its assistant director in 1966.
In 1966, President of the United States Lyndon B. Johnson nominated De Palma as Assistant Secretary of State for International Organization Affairs, and, after Senate Confirmation, De Palma held this office from February 11, 1969 until June 20, 1973.
De Palma left government service in 1973, becoming international analysis unit director of ITT Corporation. He retired in 1983.
In retirement, De Palma was president of the American and international committees of the Community of Democracies. He lived in Bethesda, Maryland until his death from pneumonia on March 21, 2002.