| Sam S. Griffin | |
| Office: | Mayor of Boise, Idaho |
| Term Start: | October 31, 1945 |
| Term End: | February 25, 1946 |
| Predecessor: | Austin Walker |
| Successor: | H. W. Whillock |
| Birth Date: | 3 January 1892[1] |
| Birth Place: | Tekamah, Nebraska, United States |
| Death Place: | Boise, Idaho, United States |
Samuel Spielman Griffin (January 3, 1892 – October 18, 1951) served briefly as mayor of Boise, Idaho, in 1945 and 1946.
Griffin succeeded Austin Walker, who died in office in October 1945. Griffin resigned four months later and was succeeded by former mayor H. W. Whillock.