| Sam Ketsekile | |
| Fullname: | Sam Ketsekile |
| Birth Date: | 8 May 1981 |
| Birth Place: | Lesotho |
| Position: | Goalkeeper |
| Currentclub: | Lesotho Prison Service |
| Years1: | 2007–2008 |
| Caps1: | 23 |
| Goals1: | 0 |
| Years2: | 2008–2009 |
| Clubs2: | Mazenod Swallows |
| Caps2: | 29 |
| Goals2: | 0 |
| Years3: | 2009– |
| Clubs3: | Lesotho Prison Service |
| Caps3: | 36 |
| Goals3: | 0 |
| Years4: | 2019- |
| Clubs4: | RBV United |
| Caps4: | 0 |
| Goals4: | 0 |
| Nationalyears1: | 2007– |
| Nationalcaps1: | 28 |
| Nationalgoals1: | 0 |
| Ntupdate: | 28 July 2023 (UTC) |
Sam Ketsekile (born 8 May 1981) is a Mosotho footballer who currently plays as a goalkeeper for Lesotho Prison Service. He has won 15 caps for the Lesotho national football team since 2007.