| Sam Barnes | |
| Position: | Second baseman |
| Bats: | Left |
| Throws: | Right |
| Birth Date: | December 18, 1899 |
| Birth Place: | Suggsville, Alabama |
| Death Place: | Montgomery, Alabama |
| Debutleague: | MLB |
| Debutdate: | September 14 |
| Debutyear: | 1921 |
| Debutteam: | Detroit Tigers |
| Finalleague: | MLB |
| Finaldate: | October 2 |
| Finalyear: | 1921 |
| Finalteam: | Detroit Tigers |
| Statleague: | MLB |
| Stat1label: | Batting average |
| Stat1value: | .182 |
| Stat2label: | Home runs |
| Stat2value: | 0 |
| Stat3label: | Runs batted in |
| Stat3value: | 0 |
| Teams: | |
Samuel Thomas Barnes (December 18, 1899 – February 19, 1981) was a Major League Baseball (MLB) player. Barnes played for the Detroit Tigers in the 1921 season.
Barnes was born in Suggsville, Alabama and died in Montgomery, Alabama. He played collegiate baseball at Auburn University, where he was named team captain.
He was the cousin of former Major Leaguer, Red Barnes.