The Santa Ana class was built for the Spanish fleet in the 1780s and 1790s as heavy ships of the line, the equivalent of Royal Navy first rate ships. The other ships of the class were the Santa Ana, Mexicano, San Hermenegildo, Conde de Regla, Real Carlos, Reina María Luisa and Príncipe de Asturias. Three of the class, including Salvador del Mundo, were captured or destroyed during the French Revolutionary Wars.
In 1797, Salvador del Mundo participated in the Battle of Cape St Vincent against the Royal Navy on 14 February under Brigadier Antonio Yepes. During the battle, Salvador del Mundo was dismasted and badly damaged before being captured by the British, with losses of 41 killed, including Yepes, and 124 wounded. William Prowse took command of the prize ship. Three other Spanish ships were captured during the battle.
Salvador de Mundo was taken into the Royal Navy under her own name and subsequently served throughout the remainder of the French Revolutionary Wars and the ensuing Napoleonic Wars on harbour duties. At the conclusion of the wars, when she was decommissioned and broken up.