Salivary duct carcinoma explained

Salivary duct carcinoma
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Salivary duct carcinoma (SDC) is a rare type of aggressive cancer that arises from the salivary glands.[1] It is predominantly seen in men and, generally, has a poor prognosis.[2] Other high grade carcinomas can mimic SDC. About 40-60% of SDC arise in pleomorphic adenomas.[3] Most, if not all, SDCs express androgen receptor by immunohistochemistry.[4] Therapeutically relevant genetic alterations include ERBB2/Her2 amplification, PIK3CA and/or HRAS mutations.[5] [6]

Signs and symptoms

The typical presentation is a rapidly growing mass with associated pain.[2] This may be seen in association with neck lymph node swelling (cervical lymphadenopathy), due to metastases, and facial nerve paralysis.

Diagnosis

SDC are diagnosed by examination of tissue, e.g. a biopsy.

Their histologic appearance is similar to ductal breast carcinoma.

See also

Notes and References

  1. Kinnera VS, Mandyam KR, Chowhan AK, Nandyala R, Bobbidi VP, Vutukuru VR . Salivary duct carcinoma of parotid gland . Journal of Oral and Maxillofacial Pathology . 13 . 2 . 85–88 . July 2009 . 21887008 . 3162867 . 10.4103/0973-029x.57676 . free .
  2. Rajesh NG, Prayaga AK, Sundaram C . Salivary duct carcinoma: correlation of morphologic features by fine needle aspiration cytology and histopathology . Indian Journal of Pathology & Microbiology . 54 . 1 . 37–41 . 2011 . 21393874 . 10.4103/0377-4929.77321 . free .
  3. Chiosea SI, Thompson LD, Weinreb I, Bauman JE, Mahaffey AM, Miller C, Ferris RL, Gooding WE . 6 . Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations . Cancer . 122 . 20 . 3136–3144 . October 2016 . 27379604 . 5048512 . 10.1002/cncr.30179 .
  4. Williams L, Thompson LD, Seethala RR, Weinreb I, Assaad AM, Tuluc M, Ud Din N, Purgina B, Lai C, Griffith CC, Chiosea SI . 6 . Salivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression . The American Journal of Surgical Pathology . 39 . 5 . 705–713 . May 2015 . 25871467 . 10.1097/pas.0000000000000413 . 24737257 .
  5. Chiosea SI, Williams L, Griffith CC, Thompson LD, Weinreb I, Bauman JE, Luvison A, Roy S, Seethala RR, Nikiforova MN . 6 . Molecular characterization of apocrine salivary duct carcinoma . The American Journal of Surgical Pathology . 39 . 6 . 744–752 . June 2015 . 25723113 . 10.1097/pas.0000000000000410 . 34106002 .
  6. Nardi V, Sadow PM, Juric D, Zhao D, Cosper AK, Bergethon K, Scialabba VL, Batten JM, Borger DR, Iafrate AJ, Heist RS, Lawrence DP, Flaherty KT, Bendell JC, Deschler D, Li Y, Wirth LJ, Dias-Santagata D . 6 . Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment . Clinical Cancer Research . 19 . 2 . 480–490 . January 2013 . 23186780 . 10.1158/1078-0432.ccr-12-1842 .

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