Salinispora tropica explained

Salinispora tropica is an obligate marine actinomycete bacterium species. It produces salinosporamide A and salinosporamide B, potential anti-cancer agents,^{[1] [2]} as well as the polycyclic macrolides sporolide A and B.^[3]

See also

• Salinispora arenicola
• Salinispora pacifica

Further reading

• Udwary DW, Zeigler L, Asolkar RN, etal . Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica . . 104 . 25 . 10376–81 . June 2007 . 17563368 . 1965521 . 10.1073/pnas.0700962104 . 2007PNAS..10410376U . free .
• Bucarey. S. A.. Penn. K.. Paul. L.. Fenical. W.. Jensen. P. R.. Genetic Complementation of the Obligate Marine Actinobacterium Salinispora tropica with the Large Mechanosensitive Channel Gene mscL Rescues Cells from Osmotic Downshock. Applied and Environmental Microbiology. 78. 12. 2012. 4175–4182. 0099-2240. 10.1128/AEM.00577-12. 22492446. 3370544.
• Thuan. Nguyen Huy. Yamaguchi. Tokutaro. Lee. Joo Ho. Sohng. Jae Kyung. Characterization of sterol glucosyltransferase from Salinispora tropica CNB-440: Potential enzyme for the biosynthesis of sitosteryl glucoside. Enzyme and Microbial Technology. 52. 4–5. 2013. 234–240. 0141-0229. 10.1016/j.enzmictec.2013.02.004. 23540924.

External links

• LPSN
  • WORMS entry
• Type strain of Salinispora tropica at BacDive - the Bacterial Diversity Metadatabase

Notes and References

1. Fenical . W. . Jensen . P.R. . Palladino . M.A. . Lam . K.S. . Lloyd . G.K. . Potts . B.C. . 2009 . Discovery and development of the anticancer agent salinosporamide A (NPI-0052) . Bioorganic & Medicinal Chemistry . 17 . 6. 2175–2180 . 10.1016/j.bmc.2008.10.075 . 19022674 . 2814440.
2. Williams PG . Buchanan GO . Feling RH . Kauffman CA . Jensen PR . Fenical W . New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica . . 70 . 16 . 6196–203 . August 2005 . 16050677 . 10.1021/jo050511+ .
3. 10.1021/ol050901i . Sporolides a and b: Structurally Unprecedented Halogenated Macrolides from the Marine Actinomycete Salinispora tropica . 2005 . Buchanan . Greg O. . Williams . Philip G. . Feling . Robert H. . Kauffman . Christopher A. . Jensen . Paul R. . Fenical . William . Organic Letters . 7 . 13 . 2731–2734 . 15957933 .