| Sakaleona River | |
| Map: | Madagascar rivers.svg |
| Subdivision Type1: | Country |
| Subdivision Name1: | Madagascar |
| Subdivision Type3: | Region |
| Subdivision Name3: | Amoron'i Mania, Vatovavy |
| Source1 Location: | near Ambositra,[1] Amoron'i Mania |
| Mouth Location: | Nosy Varika, Vatovavy |
| Mouth Coordinates: | -20.5669°N 48.5456°W |
| Basin Size: | 2314.2 km2[2] |
Sakaleona is a river in the regions of Amoron'i Mania and Vatovavy in eastern Madagascar. It flows down from the central highlands to flow into the Indian Ocean near Nosy Varika.