| Sainte-Tréphine | |
| Native Name: | Sant-Trifin |
| Commune Status: | Commune |
| Coordinates: | 48.2706°N -3.1528°W |
| Insee: | 22331 |
| Postal Code: | 22480 |
| Arrondissement: | Guingamp |
| Canton: | Rostrenen |
| Mayor: | Georges Galardon[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Kreiz-Breizh |
| Elevation Min M: | 129 |
| Elevation Max M: | 187 |
| Area Km2: | 12.52 |
Sainte-Tréphine (in French pronounced as /sɛ̃t tʁefin/;) is a commune in the Côtes-d'Armor department of Brittany in northwestern France. It is named after Saint Tryphine.
Inhabitants of Sainte-Tréphine are called tréphinois in French.